Dedifferentiated liposarcomas: evaluation of the prognostic and therapeutic factors in the elderly patient
نویسندگان
چکیده
Background Liposarcomas (LPS) are rare tumors accounting approximately for 19% of adult soft-tissue tumors [1]. The most recent classification of the WHO divides liposarcomas into 3 main clinicopatological and genetic subtypes: myxoid/round cells liposarcoma, well differentiated / dedifferentiated liposarcoma and pleomorphic liposarcoma [2]. The importance of a total macroscopical resection to perform an oncologically correct operation is well known, so that it is often necessary to remove one or more adjoining organs with the purpose of reducing the risk of local secondary recurrences [3].
منابع مشابه
High level of CDK4 amplification is a poor prognostic factor in well-differentiated and dedifferentiated liposarcoma.
The amplification of MDM2 and CDK4 is the main molecular feature of well-differentiated liposarcomas (WDLS) and dedifferentiated liposarcomas (DDLS). Although the diagnostic usefulness of this molecular characteristic in liposarcomas has been investigated, its prognostic utility of quantitative gene level has not been explored. The aim of this study was to assess the prognostic significance of ...
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