Synthesis of pyrazolone derivatives and their biological activities

3-Methyl-1-phenylpyrazol-5-one and its derivatives prepared using ethyl acetoacetate, phenyl hydrazine and its derivatives. Ethyl acetoacetate reacted with phenylhydrazine at reflux temperature to give 3-methyl-1-phenylpyrazol-5-one crude and recrystlized from diluted ethanol to give pure 3-methyl1-phenylpyrazol-5-one. Different pyrazolone derivatives were prepared by using different phenyl hydrazine derivatives. 3-methyl-1-phenylpyrazol-5-methylemine and its derivatives were prepared by 3-methyl-1-phenylpyrazol-5-one condensed with methyl amine by using methanol as media. The structures of the compounds were also elucidated. The synthesized compounds were found to have significant effect against the tested microorganisms.