“ Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation , pelvic sensitivity and changes in urinary bladder function ” by Schnegelsberg
نویسندگان
چکیده
Nerve growth factor (NGF) has been suggested to play a role in bladder pain by mediating inflammation (12) and functional changes in sensory and sympathetic neurons innervating the urinary bladder (5). Clinically, diseases such as interstitial cystitis/painful bladder syndrome (IC/PBS) have been associated with elevated urinary levels of NGF (10) and the urothelium of individuals with IC/PBS present high expression of NGF (7). In addition, NGF is thought to play a predominant role in several lower urinary tract dysfunctions, including urinary incontinence and overactive bladder symptoms such as urgency, frequency, and nocturia.
منابع مشابه
Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function.
NGF has been suggested to play a role in urinary bladder dysfunction by mediating inflammation, as well as morphological and functional changes, in sensory and sympathetic neurons innervating the urinary bladder. To further explore the role of NGF in bladder sensory function, we generated a transgenic mouse model of chronic NGF overexpression in the bladder using the urothelium-specific uroplak...
متن کاملEditorial Focus: Model for chronic overexpression of NGF challenges old paradigms: focus on “Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function”
NERVE GROWTH FACTOR (NGF) has been suggested to play a role in bladder pain by mediating inflammation (12) and functional changes in sensory and sympathetic neurons innervating the urinary bladder (5). Clinically, diseases such as interstitial cystitis/painful bladder syndrome (IC/PBS) have been associated with elevated urinary levels of NGF (10), and the urothelium of individuals with IC/PBS p...
متن کاملNeurotrophin/receptor expression in urinary bladder of mice with overexpression of NGF in urothelium.
Urothelium-specific overexpression of nerve growth factor (NGF) in the urinary bladder of transgenic mice stimulates neuronal sprouting in the urinary bladder, produces increased voiding frequency, and results in increased referred somatic hypersensitivity. Additional NGF-mediated pleiotropic changes might contribute to the increased voiding frequency and pelvic hypersensitivity observed in the...
متن کاملCALL FOR PAPERS Sensory and Effector Functions of the Urothelium Neurotrophin/receptor expression in urinary bladder of mice with overexpression of NGF in urothelium
Girard BM, Malley SE, Vizzard MA. Neurotrophin/receptor expression in urinary bladder of mice with overexpression of NGF in urothelium. Am J Physiol Renal Physiol 300: F345–F355, 2011. First published November 3, 2010; doi:10.1152/ajprenal.00515.2010.— Urothelium-specific overexpression of nerve growth factor (NGF) in the urinary bladder of transgenic mice stimulates neuronal sprouting in the u...
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Lymphoepithelial - like carcinoma, is rarely recognized in the urinary bladder and less commonly occurs with papillary transitional cell carcinoma i.e. mixed pattern. Also, less uncommon is the occurrence of carcinoma in situ changes in the adjacent urothelium of these tumors. Here, a case of lymphoepithelial – like carcinoma and papillary transitional cell carcinoma associated with carci...
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