The effects of deleterious mutations on evolution in non-recombining genomes.
نویسندگان
چکیده
Analyzing regions of the Drosophila genome that have low levels of genetic recombination helps us understand the prevalence of sexual reproduction. Here, we show that genetic variability in these regions can be explained by interference among strongly deleterious mutations and that selection becomes progressively less effective in influencing the behaviour of neighbouring sites as the number of closely linked sites on a chromosome increases.
منابع مشابه
Recombination impacts damaging and disease mutation accumulation in human populations
Many decades of theory have demonstrated that in non-recombining systems, slightly deleterious mutations accumulate non-reversibly, potentially driving the extinction of many asexual species. Non-recombining chromosomes in sexual organisms are thought to have degenerated in a similar fashion, however it is not clear the extent to which these processes operate along recombining chromosomes with ...
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ورودعنوان ژورنال:
- Trends in genetics : TIG
دوره 25 1 شماره
صفحات -
تاریخ انتشار 2009