Safety of Sildenafil for Antidepressant-Related Sexual Dysfunction

نویسنده

  • H. George Nurnberg
چکیده

Sir: I wish to call your attention to a possible safety issue in the report on the use of sildenafil for antidepressant-related sexual dysfunction. Although the authors screened their patients for medical illness and reported no serious adverse reactions to sildenafil in these antidepressant-treated subjects, the use of this agent in patients taking nefazodone (as in cases 1 and 3) may pose some risk. Nefazodone is a substantial inhibitor of the cytochrome P450 3A4 (CYP3A4) enzyme system, which also metabolizes sildenafil. In theory, this could lead to abnormally high blood sildenafil levels, which, in turn, may be associated with elevated cardiovascular risk and other adverse events. Thus, clinicians who attempt to treat sexual dysfunction with sildenafil should exercise caution when patients are taking concomitant nefazodone or other CYP3A4 inhibitors.

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Safety of Sildenafil for Antidepressant-Related Sexual Dysfunction

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تاریخ انتشار 2013