Dinucleotide repeat polymorphism in the human angiotensinogen gene.

Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans.

The renin-angiotensin system regulates blood pressure and sodium balance. The angiotensinogen gene which encodes the key substrate within this system has been linked to essential hypertension in White Europeans. It has been suggested that people of West African ancestry may have a different genetic basis for hypertension. In this study we have tested whether there is linkage of the angiotensino...

P-70: Study of GTn-Repeat Expansion in Heme Oxygenase-1 Gene Promoter As Genetic Cause of Male Infertility

Background: The length of GT-repeats polymorphic region in the promoter of human Heme oxygenase-1 gene (HO-1) alters the level of its transcriptional activity in response to oxidative stresses. Decreased level of HO-1 protein in the seminal plasma has been reported to be associated with oligospermia and azoospermia in male infertility. This is the first study to investigate the association betw...

Dinucleotide repeat polymorphism at the DXS977 locus.

Dinucleotide repeat (TG)^ polymorphism in the MAOB gene J.Grimsby, K.Chen, E.J.Devor, C.R.CIoninger and J.C.Shih Department of Molecular Pharmacology and Toxicology, University of Southern California, School of Pharmacy, Los Angeles, CA 90033, 1 Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242 and Department of Psychiatry, Washington University School of Med...

Dinucleotide repeat polymorphism in the human tubulin alpha 1 (testis specific) gene (TUBA1)

Angiotensinogen gene and hypertension in Chinese.

The renin-angiotensin system plays a major role in regulating blood pressure and maintaining electrolyte and volume homeostasis. Previously, the angiotensinogen gene, which encodes the key substrate for renin within this system, has been reported linked to and associated with essential hypertension in White Europeans, African-Caribbeans, and Japanese. Therefore, we investigated whether the angi...

Evaluation of the angiotensinogen locus in human essential hypertension: a European study.

Different family and case-control studies support genetic linkage and association at the human angiotensinogen (AGT) locus with essential hypertension. To extend these previous observations, a European collaborative study of nine centers was set up to create a large resource of affected sibling pairs. The AGT locus was studied using a highly polymorphic dinucleotide repeat in the 3'-flanking re...