The Sequence y - ( 312 - 324 ) Is a Fibrin - Specific Epitope
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چکیده
Fibrin accelerates the activation of plasminogen catalyzed by tissue-type plasminogen activator much stronger than fibrinogen. Detailed studies showed that (part of) this rateenhacing effect of fibrin is brought about by two sites in the fibrin molecule: one in Aa-(148-160) and one in the rchain stretch 31 1-379 (also known as FCB-5). During the fibrinogento-fibrin conversion, Aa-( 148-160) appears to become accessible, because a monoclonal antibody against synthetic Au-
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