2012 american college of cardiology, 61st annual scientific session & expo.
نویسنده
چکیده
Progression to MI occurred in 49% of subjects in the GIK group and in 52% of those in the placebo group (P = 0.28). Thirty-day mortality rates were 4% with GIK and 6% for placebo (P = 0.27). The endpoint of cardiac arrest or hospital mortality significantly favored GIK (4% and 6%, respectively, P = 0.01). Similar patterns were found for patients presenting with STEMI, again with a significant advantage for GIK in the endpoint of cardiac arrest or hospital mortality (6% GIK, 14% placebo; P = 0.01). Further significant benefits for GIK, compared with placebo, were reported for 30-day infarct size and FFA levels. Glucose levels above 300 mg/dL, as expected, occurred significantly more often in GIK-treated patients with and without diabetes. Rates of adverse effects with GIK were low, and the drug’s cost, Dr. Selker underscored, is low. He concluded that the risk of cardiac arrest or death was reduced by half in the IMMEDIATE trial among patients with ACS and STEMI when paramedics administered intravenous GIK as soon as possible.
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ورودعنوان ژورنال:
- P & T : a peer-reviewed journal for formulary management
دوره 37 5 شماره
صفحات -
تاریخ انتشار 2012