A statistical mechanics model for the collective epigenetic histone modification dynamics
نویسندگان
چکیده
Hang Zhang, Xiao-Jun Tian, Abhishek Mukhopadhyay, Kenneth S. Kim, Jianhua Xing 1, Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, 24061-0406, USA 2, Department of Physics, Virginia Tech, Blacksburg, Virginia, 24061-0406, USA 3, Lawrence Livermore National Laboratory and University of California, Livermore, California, USA 4, Beijing Computational Science Research Center, Beijing 100084, China
منابع مشابه
Statistical mechanics model for the dynamics of collective epigenetic histone modification.
Epigenetic histone modifications play an important role in the maintenance of different cell phenotypes. The exact molecular mechanism for inheritance of the modification patterns over cell generations remains elusive. We construct a Potts-type model based on experimentally observed nearest-neighbor enzyme lateral interactions and nucleosome covalent modification state biased enzyme recruitment...
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