The newer fluoroquinolones.
نویسنده
چکیده
Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and Streptococcus pneumonia. Important fluoroquinolone safety concerns are discussed, along with indications for the most commonly used fluoroquinolones-ciprofloxacin, levofloxacin, and moxifloxacin.
منابع مشابه
Susceptibility Trends in Respiratory Pathogens: The Role of the Newer Fluoroquinolones
ABSTRACT: Resistance to the various classes of antimicrobials continues to increase in virtually all clinically significant gram-negative and gram-positive bacteria. In particular, rates of resistance to -lactam and macrolide antimicrobial agents are on the rise among the most common bacterial pathogens, including Streptococcus pneumoniae and Haemophilus influenzae. In the bacterial cell, the f...
متن کاملPharmacokinetics and pharmacodynamics of newer fluoroquinolones.
Newer fluoroquinolones currently under development have excellent pharmacokinetic profiles, and several parameters have been improved compared with those of their predecessors. These compounds are well absorbed, have large volumes of distribution, and distribute into most tissues at concentrations equal to or greater than those observed in serum. Moreover, these newer agents have long serum eli...
متن کاملNewer fluoroquinolones and the management of respiratory tract infections.
Infections of the respiratory tract remain one of the leading causes of death in the United States [1]. The cost burden for bacterial infections of the upper and lower respiratory tract is tremendous; the cost alone of treating patients with communityacquired pneumonia (CAP) has recently been estimated to be close to $10 billion (US) [2]. In addition, the emergence of drugresistant pathogens pr...
متن کاملRole of newer fluoroquinolones in lower respiratory tract infections.
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متن کاملIn vitro activities of 11 fluoroquinolones against 226 Campylobacter jejuni strains isolated from Finnish patients, with special reference to ciprofloxacin resistance.
OBJECTIVES Although Campylobacter jejuni is naturally susceptible to fluoroquinolones, the resistance to these antimicrobials has increased rapidly during the recent years. The aim of this study was to compare the activities of various older and newer fluoroquinolones towards C. jejuni, with special attention on ciprofloxacin-resistant strains. METHODS We analysed the in vitro activities of 1...
متن کاملSkin and skin structure infections: treatment with newer generation fluoroquinolones
Skin and skin structure infections (SSSI) are an emerging issue in healthcare. They are responsible for increasing heathcare utilization, both in hospitalizations and intravenous antibiotic use. SSSI are caused by an evolving variety of pathogens, including Gram-positive, Gram-negative, and anaerobic bacteria. In combination with mounting resistance patterns, this diverse range of bacteria mand...
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ورودعنوان ژورنال:
- The Medical clinics of North America
دوره 95 4 شماره
صفحات -
تاریخ انتشار 2009