Lymphangitis-associated rickettsiosis, a new rickettsiosis caused by Rickettsia sibirica mongolotimonae: seven new cases and review of the literature.
نویسندگان
چکیده
BACKGROUND Rickettsia sibirica mongolotimonae has been found in Hyalomma ticks in Inner Mongolia (in China) and Niger and in humans in France and South Africa. To date, only 3 cases of human infection have been reported. METHODS Patients received a diagnosis of R. sibirica mongolotimonae infection on the basis of culture and/or PCR results plus serological test results. RESULTS From January 2000 to June 2004, R. sibirica mongolotimonae infection was diagnosed in 7 patients. In 3 patients, the bacterium was cultivated from the inoculation eschar. The other 4 patients had cases that were diagnosed with use of PCR of samples obtained from the eschar (2 patients) or blood (2 patients), plus specific Western blot before (2 patients) and after (2 patients) cross-adsorption. The clinical presentation included fever (temperature, >38.5 degrees C), a maculopapular rash, and > or =1 inoculation eschar in 6 patients, enlarged regional lymph nodes in 4 patients, and lymphangitis in 3 patients. On the basis of the study of 9 cases, R. sibirica mongolotimonae infection differed from other tick-borne rickettsioses in the Mediterranean area in the following ways: it involved a specific incidence in the spring, the presence of 2 eschars in 2 (22%) of the patients, the presence of a draining lymph node in 5 (55%) of the patients, and lymphangitis expanding from the inoculation eschar to the draining node in 4 (44%) of the patients. The most recent patient in our series received a clinical diagnosis on the basis of such findings. All patients recovered without any sequelae. CONCLUSIONS We propose that this new rickettsiosis be named "lymphangitis-associated rickettsiosis." Lymphangitis-associated rickettsiosis should be considered in the differential diagnosis of tick-borne rickettsioses in Europe, Africa, and Asia.
منابع مشابه
Pandemic Vibrio parahaemolyticus, Maryland, USA, 2012
1. Parola P, Paddock CD, Socolovschi C, Labruna MB, Mediannikov O, Kernif T, et al. Update on tick-borne rickettsioses around the world: a geographic approach. Clin Microbiol Rev. 2013;26:657–702. http://dx.doi.org/10.1128/CMR.00032-13 2. Wang JM, Hudson BJ, Watts MR, Karagiannis T, Fisher NJ, Anderson C et al. Diagnosis of Queensland tick typhus and African tick bite fever by PCR of lesion swa...
متن کاملRickettsia mongolotimonae: a rare pathogen in France.
We report a second case of laboratory-confirmed infection caused by Rickettsia mongolotimonae in Marseille, France. This rickettsiosis may represent a new clinical entity; moreover, its geographic distribution may be broader than previously documented. This pathogen should be systematically considered in the differential diagnosis of atypical rickettsioses, especially rashless fevers with lymph...
متن کاملRickettsia felis in Fleas, France
ity with R. sibirica subsp. mongolotimonae when compared with those in the GenBank database. Infections caused by R. sibirica subsp. mongolitimonae have been reported as lymphangitis-associated rickettsiosis (4). Our case-patient had the clinical symptoms reported for this disease: fever, maculopapular rash, eschar, enlarged satellite lymph nodes, and lymphangitis. Seasonal occurrence of this d...
متن کاملRickettsiae in Ticks, Japan, 2007–2011
were typical of lymphangitis-associated rickettsiosis, and most cases of rickettsioses in southern France in the spring are caused by R. sibirica mongolitimonae. Clustered cases of SFG rickettsiae infection have been reported in Europe, including southern France (3,6). In 2007, R. conorii and R. massiliae infections in humans were reported (3). In 2010, cases for which we were unable to discrim...
متن کاملRickettsia sibirica mongolitimonae Infection, France, 2010-2014.
To further characterize human infections caused by Rickettsia sibirica mongolitimonae, we tested skin biopsy and swab samples and analyzed clinical, epidemiologic, and diagnostic characteristics of patients with a rickettsiosis. The most common (38%) indigenous species was R. sibirica mongolitimonae. Significantly more cases of R. sibirica mongolitimonae infection occurred during spring and sum...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
دوره 40 10 شماره
صفحات -
تاریخ انتشار 2005