Bilateral Symmetrical Brain Lesions in Tricyclic Antidepressant Overdosage
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چکیده
Reprint requests to Dr. L.M. Sabet, Health Sciences Centre, Department of Pathology, London, Canada N6A 5CI. The pathophysiological effects and clinical features of overdosage with tricyclic antidepressants have been described in detail (Moraguerra, 1977; Petit, 1977; Bilgi, 1979). However, published accounts of morphological changes in the brain are scarce and lacking in detail. We are not aware of a clear description of distinctive lesions occurring as a result of overdosage with those widely used drugs. Previously published cases of fatal tricyclic antidepressant overdose in which the brain has been examined are summarized in table 1. Recently we have studied at autopsy a patient with distinctive brain lesions which appear to have been the result of selfadministered tricyclic antidepressant. This account is published so that others encountering such cases may establish if these are consistant findings.
منابع مشابه
Bilateral symmetrical brain lesions in tricyclic antidepressant overdosage.
The cerebral pathology in a case of tricyclic antidepressant overdose by amitriptyline is described. A review of the literature of similar cases is summarized. The relation of the cerebral lesions to the development of a hypertensive episode possibly induced by amitriptyline is discussed.
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