Is the Emperor Wearing Clothes?
نویسنده
چکیده
A wealth of evidence indicates that oxidized low density lipoprotein (LDL) may be of central importance in animal models of atherogenesis. In recent clinical trials, however, dietary vitamin E supplements have not consistently prevented cardiac events in humans with established coronary artery disease. Such mixed results have led many to question the role of LDL oxidation in human atherosclerosis, although this interpretation assumes that the doses of vitamin E used in the studies inhibited lipid oxidation in vivo. In fact, there is remarkably little evidence indicating that those particular regimens effectively inhibit lipid peroxidation in healthy humans. Moreover, evidence of increased oxidative stress was not a criterion for inclusion in the trials; therefore, vitamin E may have benefited only a subset of the participants. These uncertainties raise doubts about the ability of vitamin E to augment antioxidant defense mechanisms in vivo and leave many questions about LDL oxidation and atherosclerosis unanswered. (Arterioscler Thromb Vasc Biol. 2001;21:1261-1264.)
منابع مشابه
Current definitions of central line-associated bloodstream infection: is the emperor wearing clothes?
Wearing Clothes? • Author(s): Daniel J. Sexton , MD, Luke F. Chen , MBBS, MPH, CIC, FRACP, Deverick J. Anderson , MD, MPH Source: Infection Control and Hospital Epidemiology, Vol. 31, No. 12 (December 2010), pp. 1286-1289 Published by: The University of Chicago Press on behalf of The Society for Healthcare Epidemiology of America Stable URL: http://www.jstor.org/stable/10.1086/657583 . Accessed...
متن کاملEfficacy of Permethrin-impregnated clothes in prevention of cutaneous Leishmaniasis: A randomized, double-blind clinical trial
Background: Some researchers claim that permethrin-impregnated clothes are effective in the prevention of cutaneous leishmaniasis. Objectives: To determine the effectiveness of permethrin-impregnated clothes in the prevention of cutaneous leishmaniasis. Patients and Methods: 272 soldiers were randomized in two groups. In one group permethrin-impregnated clothes and in the other group, control c...
متن کاملA first stage in collecting data showing that software is the major source of difficult problems and operational performance p
“You software guys are too much like the weavers in the story about the Emperor and his new clothes. When I go out to check on a software development the answers I get sound like, ‘We’re fantastically busy weaving this magic cloth. Just wait a while and it’ll look terrific.’ But there’s nothing I can see or touch, no numbers I can relate to, no way to pick up signals that things aren’t really a...
متن کاملEnclothed cognition
a r t i c l e i n f o We introduce the term " enclothed cognition " to describe the systematic influence that clothes have on the wearer's psychological processes. We offer a potentially unifying framework to integrate past findings and capture the diverse impact that clothes can have on the wearer by proposing that enclothed cognition involves the co-occurrence of two independent factors—the s...
متن کامل