ABC Transporter Genes and Risk of Type 2 Diabetes A study of 40,000 individuals from the general population
نویسندگان
چکیده
RESEARCH DESIGN AND METHODSdWe tested whether genetic variation in the promoter and coding regions of ABCA1 and ABCG1 predicted risk of type 2 diabetes in the general population. Twenty-seven variants, identified by previous resequencing of both genes, were genotyped in the Copenhagen City Heart Study (CCHS) (n = 10,185). Two loss-of-function mutations (ABCA1 N1800H and ABCG1 g.-376C.T) (n = 322) and a common variant (ABCG1 g.-530A.G) were further genotyped in the Copenhagen General Population Study (CGPS) (n = 30,415).
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