Bacterial Toxicity of Potassium Tellurite: Unveiling an Ancient Enigma

Site-Directed Mutagenesis as a Tool for Unveiling Mechanisms of Bacterial Tellurite Resistance

Proteomic Differences between Tellurite-Sensitive and Tellurite–Resistant E.coli

Tellurite containing compounds are in use for industrial processes and increasing delivery into the environment generates specific pollution that may well result in contamination and subsequent potential adverse effects on public health. It was the aim of the current study to reveal mechanism of toxicity in tellurite-sensitive and tellurite-resistant E. coli at the protein level. In this work a...

DNA, Cell Wall and General Oxidative Damage Underlie the Tellurite/Cefotaxime Synergistic Effect in Escherichia coli

The constant emergence of antibiotic multi-resistant pathogens is a concern worldwide. An alternative for bacterial treatment using nM concentrations of tellurite was recently proposed to boost antibiotic-toxicity and a synergistic effect of tellurite/cefotaxime (CTX) was described. In this work, the molecular mechanism underlying this phenomenon is proposed. Global changes of the transcription...

Unveiling the cycle of dimethylsulfoniopropionate in the North Pacific Subtropical Gyre

A longstanding scientific enigma exists in oligotrophic subtropical waters: it appears that bacterial respiration contributes up to 90% of total community respiration even though the contribution of bacterial biomass to total biomass is much less. It has been suggested that experimental artifacts including pre-incubation filtration procedures, applied in order to separate bacteria from the rest...

Tellurite-mediated thiol oxidation in Escherichia coli.

The oxyanion of tellurium, tellurite (TeO3(2-)), is toxic to most micro-organisms, particularly gram-negative bacteria. The mechanism of tellurite toxicity is presently unknown. Many heavy metals and oxyanions, including tellurite, interact with reduced thiols (RSH). To determine if tellurite interaction with RSH groups is involved in the toxicity mechanism, the RSH content of Escherichia coli ...