Experimental Studies: Animal Tumors
نویسنده
چکیده
Studies in Cucinogenesis. V. Methyl Derivatives of 1 : 2-Benzanthracene, M. J. SHEAR. In a further contribution to his series of studies on carcinogenesis Shear records his experiments with the methyl derivatives of 1 : 2-benzanthracene and related compounds. Of 21 compounds examined 10 produced tumors in mice a t the injection site. The more potent carcinogenic compounds were 5 : 10-dimethyl-1 : 2-benzanthracene, 5-methyl-1 : 2-benzanthracene, 10-methyl-1 : 2-benzanthracene, 5 : 9-dimethyl-1 : 2benzanthracene, 9-methyl-1 : 2-benzanthracene, 4-10-ace-1 : 2-benzanthracene, 1' : 2' : 3' : 4'-tetrahydro-4 : 10-ace-1 : 2-benzanthracene, 20-ethylcholanthrene. Tumors were also produced by 7-methyl1 : 2-benzanthracene and 9 : 10-dimethyl-1 : 2-benzanthracene. Photomicrographs are included and there is a comprehensive bibliography. Am. J. Cancer 33: 499-537, 1938.
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