Title : Chronic methadone treatment shows a better cost : benefit ratio than chronic morphine in mice

نویسندگان

  • Johan Enquist
  • Madeline Ferwerda
  • Laura Milan-Lobo
  • Jennifer L Whistler
  • Ernest Gallo
  • Jennifer Whistler
چکیده

Text pages 29 Tables 1 Figures 4 References 45 Word count: Abstract 190 Introduction 528

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Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice.

Chronic treatment of pain with opiate drugs can lead to analgesic tolerance and drug dependence. Although all opiate drugs can promote tolerance and dependence in practice, the severity of those unwanted side effects differs depending on the drug used. Although each opiate drug has its own unique set of pharmacological profiles, methadone is the only clinically used opioid drug that produces su...

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 Background: Today opioids are used to control and relieve acute and chronic pain. However, the incidence of both tolerance and dependence phenomena are the two major problems in the people who take these drugs. So, in this study the combination effect of haloperidol and methadone on the acquisition and expression of morphine dependence and tolerance have been examined. Methods: In thi...

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The effect of methadone and haloperidol combination on anxiety induced by morphine withdrawal in male mice

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  Background and Objective: Tolerance and dependence are two major problems of chronic opioids use. Repeated application of Lavandula officinalis has been recommended for a long time in Iranian traditional medicine for some of nervous disorders like epilepsy and dementia. Since anti-convulsant drugs are beneficial in treatment of morphine dependence and with regard to anti-convulsant effec...

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تاریخ انتشار 2011