16-P008 Cilia-dependent olfactory bulb morphogenesis
نویسندگان
چکیده
septum formation. Migration assays performed on primary cell cultures of myofibroblasts from wild type and Rfx3 / lungs show that Rfx3 / myofibroblasts loose their capacities to respond to environmental factors as guidance cues. We are currently dissecting the signaling cascades that are impaired in Rfx3-deficient myofibroblasts. In conclusion, RFX3 regulates primary ciliary growth and governs myofibroblast differentiation program in the developing lungs. Our work therefore suggests a novel function of primary cilia during lung development in vivo.
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ورودعنوان ژورنال:
- Mechanisms of Development
دوره 126 شماره
صفحات -
تاریخ انتشار 2009