Characterisation of CorGlaes® Pure 107 fibres for biomedical applications
نویسندگان
چکیده
A degradable ultraphosphate (55 mol % P2O5) quinternary phosphate glass composition has been characterised in terms of its chemical, mechanical and degradation properties both as a bulk material and after drawing into fibres. This glass formulation displayed a large processing window simplifying fibre drawing. The fibres displayed stiffness and strength of 65.5 ± 20.8 GPa and 426±143 MPa. While amorphous discs of the glass displayed a linear dissolution rate of 0.004 mg cm(-2) h(-1) at 37 °C, in a static solution with a reduction in media pH. Once drawn into fibres, the dissolution process dropped the pH to <2 in distilled water, phosphate buffer saline and corrected-simulated body fluid, displaying an autocatalytic effect with >90 % mass loss in 4 days, about seven times faster than anticipated for this solution rate. Only cell culture media was able to buffer the pH taking over a week for full fibre dissolution, however, still four times faster dissolution rate than as a bulk material. However, at early times the development of a HCA layer was seen indicating potential bioactivity. Thus, although initial analysis indicated potential orthopaedic implant applications, autocatalysis leads to accelerating degradation in vitro.
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Fatemeh Karimi was born in 1984 in Shahreza/ Isfahan, Iran. She received her B.Sc. in pure Chemistry (2006) and M.Sc. in Organic Chemistry (2008) from Isfahan University of Technology, Iran, under the supervision of professor Abdol Reza Hajipour. She is currently working towards her Ph.D. under the supervision of professor Mohammad Ali Zolfigol at Bu-Ali Sina University. Her research interest i...
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