Acute and delayed IPC enhance performances
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Os003 Ipc Reduces Iri in the Rat Kidney Byrepressing Its Unique Microrna Expression Profile
Background: MicroRNAs are important post-transcriptional regulators of gene expression, implicated in many physiological and pathophysiological processes, including kidney disease. Ischaemia reperfusion injury (IRI) is an inevitable consequence of transplantation and results in delayed graft function and primary non-function. The aim of this research was to characterise the role of microRNAs in...
متن کاملRole of miR-21 on vascular endothelial cells in the protective effect of renal delayed ischemic preconditioning
Vascular endothelial cells may serve crucial roles in the development of acute kidney injury (AKI). microRNA (miR)‑21, which possesses a renal protective function has been found on vascular endothelial cells. The present study aimed to test the hypothesis that miR‑21 may protect vascular endothelial cells against injury, which may contribute to the protective effects of renal delayed ischemic p...
متن کاملRenalase contributes to the renal protection of delayed ischaemic preconditioning via the regulation of hypoxia-inducible factor-1α
Ischaemic preconditioning (IPC) attenuates acute kidney injury (AKI) from renal ischaemia reperfusion. Renalase, an amine oxidase secreted by the proximal tubule, not only degrades circulating catecholamines but also protects against renal ischaemia reperfusion injury. Here, it has been suggested that the renoprotective effect of renal IPC is partly mediated by renalase. In a model of brief int...
متن کاملRemote preconditioning and delayed cardioprotection in skeletal muscle.
THE CONCEPT OF ISCHEMIC PRECONDITIONING (IPC) was introduced in 1986 by Murry, Jennings, and Reimer (10). These investigators showed that four brief 5-min periods of ischemia in canine hearts produced a marked reduction in myocardial infarct size in dogs subjected to 40 min of coronary artery occlusion and 72 h of reperfusion compared with a nonpreconditioned group. This finding has stimulated ...
متن کاملSarcolemmal K(ATP) channel triggers opioid-induced delayed cardioprotection in the rat.
Recently, the involvement of sarcolemmal K(ATP) (sarcK(ATP)) channels in ischemic and pharmacological preconditioning (IPC and PPC) has been minimized by numerous studies suggesting a primary role for mitochondrial K(ATP) (mitoK(ATP)) channels in early and delayed cardioprotection. Although the mitoK(ATP) channel has clearly been shown to be a distal effector of delayed IPC and PPC, studies imp...
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