Evaluating the relationship of high-dose venlafaxine prescribing to treatment-resistant depression

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AIMS AND METHOD Prescribing of venlafaxine inThe South London and Maudsley NHS Trust was found to account for over 50% of the antidepressant costs, but only 15% of the prescriptions.There is evidence to suggest that higher doses of venlafaxine may be effective in treating treatment-refractory depression.We aimed to discover if higher doses of venlafaxine used in the trust were related to prior failure to respond to antidepressant treatment. Hospital in-patients being treated with venlafaxine during a 1-week period in October 2001were identified and case notes were reviewed to determine patient demographic data and prior history of antidepressant therapy.

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تاریخ انتشار 2003