Dynamic observation on primitive fibrinogen and antithrombin III activity in premature infants

Objective: To detect the changes of plasma fibrinogen and antithrombin III activity in premature infants of different gestational age and those with maternal pregnancy-induced hypertension (PIH) or not after birth, and discuss its clinical significance. Method: 51 premature infants with gestational age of less than 34 weeks and 45 premature infants of 34-37 weeks were selected. Based on whether their mothers had PIH or not, they were divided into PIH group (50 cases) and absent PIH group (46 cases), respectively. The plasma fibrinogen and antithrombin III activity were measured within 24 hours and on day 5 after birth, respectively. Results: The plasma fibrinogen and antithrombin III activity of premature infants within 24 hours and on day 5 after birth were at lower levels. The plasma fibrinogen and antithrombin III activity among premature infants with gestational age of less than 34 weeks were lower than those among premature infants of 34-37 weeks, with significant differences. Moreover, the plasma fibrinogen and antithrombin III activity of premature infants within 24 hours and on day 5 after birth among maternal PIH group were lower than those among absent PIH group, respectively, with significant differences (P<0.05). Conclusion: Dynamic detection of plasma fibrinogen and antithrombin III activity in premature infants after birth is significant to prevent hemorrhagic syndrome of premature infants, but its diagnostic value in disseminated intravascular coagulation remains to be further investigated.