FMRP Regulates Neurogenesis in Vivo in Xenopus Laevis Tadpoles FMRP Regulates Neurogenesis in Vivo in Xenopus
نویسندگان
چکیده
Author contributions: R.L.F., T.J.W., C.K.T., H.-H.L., and H.T.C. designed research; R.L.F., T.J.W., C.K.T., and H.-H.L. performed research; R.L.F., T.J.W., C.K.T., and H.-H.L. analyzed data; R.L.F. and H.T.C. wrote the paper. Funding: NEI EY011261 Funding: NIEHS K99ES022992 Funding: NINDS F32NS071807 Funding: NIGM T34GM087193 Funding: DOD | U.S. Army | U.S. Army Materiel Command (AMC) 100006753 W81XWH-12-1-0207 Funding: CIRM TG2-01165
منابع مشابه
FMRP regulates neurogenesis in vivo in Xenopus laevis tadpoles.
Fragile X Syndrome (FXS) is the leading known monogenic form of autism and the most common form of inherited intellectual disability. FXS results from silencing the FMR1 gene during embryonic development, leading to loss of Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein that regulates mRNA transport, stability, and translation. FXS is commonly thought of as a disease of syn...
متن کاملFMRP Regulates Neurogenesis In Vivo in Xenopus laevis Tadpoles1,2,3
Fragile X Syndrome (FXS) is the leading known monogenic form of autism and the most common form of inherited intellectual disability. FXS results from silencing the FMR1 gene during embryonic development, leading to loss of Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein that regulates mRNA transport, stability, and translation. FXS is commonly thought of as a disease of syn...
متن کاملFragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells
Fragile X syndrome (FXS), the most common form of inherited mental retardation, is caused by the loss of functional fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein that can regulate the translation of specific mRNAs. Adult neurogenesis, a process considered important for neuroplasticity and memory, is regulated at multiple molecular levels. In this study, we investig...
متن کاملAn in vivo screen to identify candidate neurogenic genes in the developing Xenopus visual system
Neurogenesis in the brain of Xenopus laevis continues throughout larval stages of development. We developed a 2-tier screen to identify candidate genes controlling neurogenesis in Xenopus optic tectum in vivo. First, microarray and NanoString analyses were used to identify candidate genes that were differentially expressed in Sox2-expressing neural progenitor cells or their neuronal progeny. Th...
متن کاملIn Vivo Analysis of the Neurovascular Niche in the Developing Xenopus Brain
The neurovascular niche is a specialized microenvironment formed by the interactions between neural progenitor cells (NPCs) and the vasculature. While it is thought to regulate adult neurogenesis by signaling through vascular-derived soluble cues or contacted-mediated cues, less is known about the neurovascular niche during development. In Xenopus laevis tadpole brain, NPCs line the ventricle a...
متن کامل