Low base-substitution mutation rate in the ciliate Tetrahymena thermophila
نویسندگان
چکیده
Mutation is the ultimate source of all genetic variation and is, therefore, central to evolutionary change. Previous work on the ciliate Paramecium tetraurelia concluded that the presence of a transcriptionally silent germline genome has caused the evolution of a low base-substitution mutation rate in the germline genome of that ciliate. Here, we use mutation accumulation (MA) lines of the ciliate Tetrahymena thermophila to test the generality of this result. We find that both ciliates have similar base-substitution mutation rates in their germline genomes. The estimated base-substitution mutation rate cannot account for the observed fitness decline of the MA lines of T. thermophila, suggesting that the fitness decline may be caused by other factors.
منابع مشابه
Low base-substitution mutation rate in the germline genome of the ciliate Tetrahymena thermophila
CC-BY 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not. 2 ABSTRACT Mutation is the ultimate source of all genetic variation and is, therefore, central to evolutionary change. Previous work on Paramecium tetraurelia found an unusually low germline base-substitution mutation rate in this ciliate. Here...
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Mutation is the ultimate source of all genetic variation and is, therefore, central to evolutionary change. Previous work on Paramecium tetraurelia found an unusually low germline base-substitution mutation rate in this ciliate. Here, we tested the generality of this result among ciliates using Tetrahymena thermophila. We sequenced the genomes of 10 lines of T. thermophila that had each undergo...
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