GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis.

Autoimmune Encephalomyelitis Cells and the Onset of Experimental Is Required for the Activation of Microglial GM-CSF Production by Autoreactive T Cells

Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation

TH1 and TH17 cells mediate neuroinflammation in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Pathogenic TH cells in EAE must produce the pro-inflammatory cytokine granulocyte-macrophage colony stimulating factor (GM-CSF). TH cell pathogenicity in EAE is also regulated by cell-intrinsic production of the immunosuppressive cytokine interleukin 10 (IL-10). ...

P 113: Effect of Curcumin on Microglial Cells in MS

Multiple sclerosis (MS) is the most common autoimmune disease, especially among young’s. Neuroinflammation results from inflammation in CNS and it may cause different disorders and diseases .It is also known as a detriment in multiple sclerosis. In fact, it causes problems and symptoms in MS. In MS the self-immune cells attack the myelin of neurons, it maybe the nerve in brain or spinal c...

O17: Inflammation in Brain and Spinal Cord

our goal in this paper is to describe and compare basic immunopathologic pattern of common demyelinating disorder, that is very important to choose the best treatment. The most common disorders are multiple sclerosis, neuromyelitis optica,Anti MOG associated disease,ADEM and autoimmune encephalitis. ADEM consists of ‘‘sleeves’’ of demyelination centered on small, engorge...

Inflammasome-derived IL-1β regulates the production of GM-CSF by CD4(+) T cells and γδ T cells.

Recent findings have demonstrated an indispensable role for GM-CSF in the pathogenesis of experimental autoimmune encephalomyelitis. However, the signaling pathways and cell populations that regulate GM-CSF production in vivo remain to be elucidated. Our work demonstrates that IL-1R is required for GM-CSF production after both TCR- and cytokine-induced stimulation of immune cells in vitro. Conv...