Investigations on West African medicinal plants
نویسندگان
چکیده
We report on the isolation and structural determination of and synthetic studies with constituents of the West African medicinal plants Tabernaemontan glandulosa, Carissa edulis (Apocynaceae), Canthium subcordatum (Rubiaceae), Hexalobus crispiflorus (Annonaceae), Uvaria elliotiana (Annonaceae), Annonidium manii (Annonaceae), Cochlospermum planchonii (Cochlospermaceae) and Iboza riparia (Labiatae). This report deals with investigations on West African medicinal plants. We started this work about 8 years ago in cooperation with people from the University of Ghana. Today I would like to report on some details of what we have done with special emphasis on some of our most recent results. Tabernaemontana glandulos is a shrub which belongs to the Apocynaceae family. Parts of the plant are used in folk medicine against various diseases. From the stems and leaves we isolated as a main constituent tabernusoline, a new alkaloid. In pharmacological tests, tabernulosine causes a significant hypotensive effect, when injected intravenously into genetic hypertonic rats (Fig. 1). After a single dose, the blood pressure falls by 25 mm Hg, and remains at this lower level for a considerable time.
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