Serotonin & developmental axonal refinement : microglia contribution ?
نویسندگان
چکیده
............................................................................................................................................................. 1 A INDRODUCTION ....................................................................................................................................... 3 A1 Microglia .................................................................................................................................................. 5 A1.1 Microglia History ...................................................................................................................... 5 A1.2 Developmental Origin of Microglia ................................................................................... 6 A1.2.1 Microglia Originate from Extra-Embryonic Yolk Sac ............................................. 6 A1.2.2 Transition to the Committed Microglia Progenitors .............................................. 8 A1.2.3 Microglia Brain Colonization ........................................................................................... 9 A1.3 Microglia in Adult Brain ....................................................................................................... 11 A1.3.1 Origin of Microglia in Adult Brain ............................................................................... 11 A1.3.2 Adult Microglial Phenotype ........................................................................................... 13 A1.3.3 Microglia in Non-Pathological Conditions................................................................ 14 A1.3.4 Microglia Activation .......................................................................................................... 16 A1.3.5 Microglia Activation Markers ........................................................................................ 18 A1.3.6 Microglia vs. Macrophages ............................................................................................. 19 A1.4 Early Postnatal Microglia .................................................................................................... 21 A1.4.1 Developmental Microglial Phenotype ........................................................................ 21 A1.4.2 Developmental Neuronal Survival .............................................................................. 23 A1.4.3 Synaptogenesis, Synaptic Maturation & Plasticity during Development ..... 24 A1.4.4 Neurogenesis & Plasticity in Adult Brain ................................................................. 25 A2 Serotonin ............................................................................................................................................... 29
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