Estimation in adaptive group sequential trials
نویسندگان
چکیده
2 Group Sequential Designs (GSD) 2 2.1 GST object . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2.1.1 Alpha spending function (SF) . . . . . . . . . . . . . . . . 4 2.2 plan.GST example . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.3 Overall p-values for GSDs . . . . . . . . . . . . . . . . . . . . . . 6 2.3.1 Repeated p-values in a classical GSD . . . . . . . . . . . . 6 2.3.2 P -value based on the stage-wise ordering in a classical GSD 7 2.4 Construction of one sided confidence intervals for GSDs . . . . . 7 2.4.1 Classical repeated confidence bounds . . . . . . . . . . . . 7 2.4.2 Classical stage-wise confidence bounds . . . . . . . . . . . 8 2.5 Point estimates for GSDs . . . . . . . . . . . . . . . . . . . . . . 8 2.5.1 Median unbiased point estimate . . . . . . . . . . . . . . 8 2.5.2 Conservative point estimate . . . . . . . . . . . . . . . . . 8 2.6 Summary function for a GST object . . . . . . . . . . . . . . . . 9
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تاریخ انتشار 2011