Modulation of proteasome machinery by natural and synthetic analogues of the marine bioactive compound petrosaspongiolide M.
نویسندگان
چکیده
Natural or synthetic? Several petrosaspongiolide M natural and synthetic analogues have been tested as proteasome inhibitors and apoptosis modulators. The natural petrosaspongiolide M congeners gave a consistent decrease in activity. Among the synthetic analogues, the introduction of the benzothiophene ring resulted in a bioequivalent alternative of the petrosaspongiolide M terpenoid system.
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ورودعنوان ژورنال:
- Chembiochem : a European journal of chemical biology
دوره 13 7 شماره
صفحات -
تاریخ انتشار 2012