Toxicity of 2-mercaptopropionylglycine (MPG) on mouse liver.

Undertaken study deals with any vulnerable changes by the radioprotective drug 2-mer captopropionylglycine, after administering in variable concentration (20, 50, 100, 200 and 500 mg/kg body weight) of the liver of adult mice at 1, 3, 7 and 14 days interval. The lower doses, 20 and 50 mg/kg body-weight of MPG did not affect the liver at all while at higher doses of 100, 200 and 500 mg/kg body-weight of MPG, liver showed many histopathological changes in the form of cytoplasmic degranulation and vacuolation, pyknotic, necrotic, crenated and hypertypic nuclei, hyperaemia, and lymphocytic infiltration etc. These damages were found to be irreversible at the dose level of 500 mg/kg body-weight at the last interval studied.