University of Groningen Formation of Cerebrovascular Anomalies in the Ageing Rat is Delayed by Chronic Nimodipine Application
نویسندگان
چکیده
منابع مشابه
Formation of cerebrovascular anomalies in the ageing rat is delayed by chronic nimodipine application.
At the ultrastructural level two main categories of microvascular anomalies can be distinguished in the aged rat brain. These categories comprise [1] membranous inclusions within the basement membrane and [2] microvascular deposits, which include microvascular fibrosis and thickening of the basement membrane (BMT). In this study we examined the percentage of microvessels displaying ageing-relat...
متن کاملCerebral Ischemia/Reperfusion Injury in the Hyperthyroid Rat
Background: Hyperthyroidism as a risk factor for stroke is not conclusive. There are no definite data on the relationship between ischemic cerebrovascular injury and hyperthyroidism. This study was designed to define whether the outcomes of post-ischemic stroke injury are influenced by chronic hyperthyroidism. Methods: Two groups of hyperthyroid (HT) and control euthyroid rats of equal numbers ...
متن کاملDevelopment of an RP-HPLC-UV method for simultaneous detection of nimodipine and its metabolite in cerebrospinal fluid of rat
A rapid, simple and reproducible HPLC method was developed and validated for the analysis of nimodipine (NM) and/or its metabolite, oxidized nimodipine (OX–NM) in rat cerebrospinal fluid (CSF) and artificial CSF. The NM and OX–NM were eluted in less than 10 min with no interferences from the endogenous CSF peaks. Analysis was carried out on a Eurospher Performance (RP-C18, 250 × 4.6 mm) column ...
متن کاملMelatonin Reduces Cataract Formation and Aldose Reductase Activity in Lenses of Streptozotocin-induced Diabetic Rat
Background: The relationship between the high activity of aldose reductase (AR) and diabetic cataract formation has been previously investigated. The purpose of the present study was to determine the preventing effect of melatonin on streptozotocin (STZ)-induced diabetic cataract in rats.Methods: 34 adult healthy male Sprague-Dawely rats were divided into four groups. Diabetic control and diabe...
متن کاملDevelopment of an RP-HPLC-UV method for simultaneous detection of nimodipine and its metabolite in cerebrospinal fluid of rat
A rapid, simple and reproducible HPLC method was developed and validated for the analysis of nimodipine (NM) and/or its metabolite, oxidized nimodipine (OX–NM) in rat cerebrospinal fluid (CSF) and artificial CSF. The NM and OX–NM were eluted in less than 10 min with no interferences from the endogenous CSF peaks. Analysis was carried out on a Eurospher Performance (RP-C18, 250 × 4.6 mm) column ...
متن کامل