Nanostructured Boron Nitride With High Water Dispersibility For Boron Neutron Capture Therapy
نویسندگان
چکیده
Highly water dispersible boron based compounds are innovative and advanced materials which can be used in Boron Neutron Capture Therapy for cancer treatment (BNCT). Present study deals with the synthesis of highly water dispersible nanostructured Boron Nitride (BN). Unique and relatively low temperature synthesis route is the soul of present study. The morphological examinations (Scanning/transmission electron microscopy) of synthesized nanostructures showed that they are in transient phase from two dimensional hexagonal sheets to nanotubes. It is also supported by dual energy band gap of these materials calculated from UV- visible spectrum of the material. The theoretically calculated band gap also supports the same (calculated by virtual nano lab Software). X-ray diffraction (XRD) analysis shows that the synthesized material has deformed structure which is further supported by Raman spectroscopy. The structural aspect of high water disperse ability of BN is also studied. The ultra-high disperse ability which is a result of structural deformation make these nanostructures very useful in BNCT. Cytotoxicity studies on various cell lines (Hela(cervical cancer), human embryonic kidney (HEK-293) and human breast adenocarcinoma (MCF-7)) show that the synthesized nanostructures can be used for BNCT.
منابع مشابه
An Assessment of the Potential Use of BNNTs for Boron Neutron Capture Therapy
Currently, nanostructured compounds have been standing out for their optical, mechanical, and chemical features and for the possibilities of manipulation and regulation of complex biological processes. One of these compounds is boron nitride nanotubes (BNNTs), which are a nanostructured material analog to carbon nanotubes, but formed of nitrogen and boron atoms. BNNTs present high thermal stabi...
متن کاملPlant-Based Calcium Fructoborate as Boron-Carrying Nanoparticles for Neutron Cancer Therapy
Boron neutron capture therapy (BNCT) is an effective clinical method in cancer treatment based on fission reactions and nuclear capturing. In this method, use of the best boron-containing agents for boron therapy and boron delivery agent for transfer to the infectious site are the key points for efficienct treatment. Our research indicated that calcium fructoborate(CF) was the best compound as...
متن کاملPreparation and characterization of Au nanoparticles capped with mercaptocarboranyl clusters.
The preparation of 3-4 nm and 10 nm gold nanoparticles capped with neutral carborane-based mercaptocarboranes, via two different preparative routes, is reported. The resulting boron-enriched nanomaterials exhibit complete dispersibility in water, opening the way for the use of these monolayer protected clusters (MPCs) in medical applications, such as boron neutron capture therapy (BNCT). These ...
متن کاملSimulation of Hydrogenated Boron Nitride Nanotube’s Mechanical Properties for Radiation Shielding Applications
Radiation shielding is an obstacle in long duration space exploration. Boron Nitride Nanotubes (BNNTs) have attracted attention as an additive to radiation shielding material due to B’s large neutron capture cross section. The B has an effective neutron capture cross section suitable for low energy neutrons ranging from 10 to 10 eV and hydrogen is effective at slowing down high energy neutrons....
متن کاملBoron-nitride nanotube triggered self-assembly of hexagonal boron-nitride nanostructure.
Molecular mechanics results show that a hexagonal boron nitride (h-BN) membrane can spontaneously assemble on the single-walled boron nitride nanotube (BNNT) in a scroll or helical manner, showing an interesting dependence on h-BN width. The size of BNNTs should meet the required conditions to guarantee self-assembly. Further analyses of energy components and structural geometry show that this ...
متن کامل