An Update on Ligands for Prostanoid Receptors
نویسندگان
چکیده
T he natural prostanoids arise from the activity of intracellular cyclo-oxygenase (COX) on polyunsaturated fatty acids released from membrane phospholipids. In the case of the most important substrate, arachidonic acid (20:4ω6), the first product is prostaglandin G2 (PGG2), which is then reduced to PGH2 by an associated 15-hydroperoxidase [1]. Depending on the tissue, PGH2 may be further metabolized by isomerases to PGD2, PGE2, PGI2 (prostacyclin and TXA2 and by a reductase to PGF2α.
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