Crosslinked poly ( ester anhydrides ) for controlled drug delivery

DOCTORAL DISSERTATIONS A ato-D D 10 /2 13 Bioresorbable polymers are extensively studied materials for medical applications. In this thesis, novel bioresorbable polymers, hydrophobically-modified crosslinked poly(ester anhydride) networks, were developed and characterized with the aim of obtaining suitable matrices for drug release applications. In these poly(ester anhydride) networks were combined the favorable characteristics of synthetic aliphatic polyesters and polyanhydrides. The properties of the networks were altered by modifying the structure of the poly(epsiloncaprolactone) oligomers which were used in the preparation of the crosslinked poly(ester anhydride) networks. The developed crosslinked poly(ester anhydride) networks were demonstrated to have high potential for applications requiring controlled release of sensitive macromolecular pharmaceutical agents. R sto H aala