Topical diltiazem in management of chronic anal fissure: a review of the literature
نویسنده
چکیده
2014 Anal fissure is a common painful anorectal condition which affects people of various age groups, and deteriorates their quality of life. Chronic anal fissure requires medical intervention either by pharmacotherapy or by surgery. Various pharmacological agents have been used in the treatment of chronic anal fissure with the aim of relaxation of internal anal-sphincter smooth muscle. Diltiazem is a calcium-channel blocker that has been tried in several clinical studies for management of chronic anal fissure. This review focuses on the available literature data on the use of topical diltiazem (cream, gel, ointment) in the treatment of chronic anal fissure in order to give an overall viewpoint of the work carried on in this field and the results obtained.
منابع مشابه
مقایسه اثر درمان جراحی اسفنکتروتومی داخلی و درمان طبی با ژل دیلتیازم در شقاق مزمن مقعد
Comparison Between the Therapeutic Effects of Internal Sphincterotomy and Diltiazem Gel in Chronic Anal Fissure M.A. Rajabi MD Received: 15/08/06 Sent for Revision: 18/10/06 Received Revised Manuscript: 15/05/07 Accepted: 29/05/07 Background and Objective: Surgery is now the "treatment of choice" for chronic anal fissure. However, considering the pathogenesis of this disease and the tendency fo...
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OBJECTIVE To assess and compare the effectiveness of topical 0.2% glycerl trinitrate (GTN) and topical 2% diltiazem (DTZ), in the management of chronic anal fissure. STUDY DESIGN Comparative, descriptive study. PLACE AND DURATION OF STUDY Department of Surgery, Liaquat University of Medical and Health Sciences, Jamshoro/Hyderabad from September 2004 to August 2005. METHODOLOGY Patients wi...
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مقایسه میزان بهبودی و عوارض ناشی از درمان بیماران مبتلا به شقاق مزمن مقعد در دو روش استفاده از پماد 03/0%GTN و ژل دیلتیازم 2%
Introduction: In this randomized prospective study, 2% - diltiazem topical gel and 0.03% -GTN ointment were compared in patients with chronic anal fissure. Methods: This semi-experimental study consisted of sixty six outpatients (34 females and 32 males) with chronic anal fissure, who referred to the gastroenterology clinic. Patients were randomly classified into two groups. Group A received G...
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