Infection with Histoplasma capsulatum: Host-fungus interface.

Histoplasma capsulatum is a pathogenic fungus that has caused infections in all continents except Antarctica although most disease is found within the Americas. It produces a broad spectrum of illness that can on occasion be fatal. Understanding the interaction between the host and the fungus provides insights into the pathogenic mechanisms as well as the host response to replicating fungi. This knowledge can be used to improve treatment as well as diagnosis. Hence, this review summarizes some of the most recent findings regarding host-fungus interaction.