XenomiRs and miRNA homeostasis in health and disease
نویسنده
چکیده
Contributions of dietary miRNAs to circulating small RNA profiles would have profound implications for interpretation of miRNA biomarker studies: presumptive disease-specific markers might instead indicate responses to disease-associated quantitative or qualitative dietary alteration. This examination weighs the evidence for a 2-fold hypothesis: first, that ingested biological matter contributes directly to the miRNA complement of body compartments; and second, that these diet-derived exogenous miRNAs (or "xenomiRs") affect total miRNA profiles as part of a circulating miRNA homeostasis that is altered in many diseases. Homeostasis of high-density lipoprotein (HDL), a known miRNA carrier-provides a model as a proposed component of broader miRNA homeostasis. Further research into the dietary xenomiR hypothesis is needed to ensure rigor in the search for truly disease-specific miRNA biomarkers.
منابع مشابه
Real-time quantitative PCR and droplet digital PCR for plant miRNAs in mammalian blood provide little evidence for general uptake of dietary miRNAs Limited evidence for general uptake of dietary plant xenomiRs
In 2012 L. Zhang et al. presented the hypothesis that plant miRNAs are transferred into blood and then tissue from dietary sources. Not only did the authors report detection of plant miRNA in animals, they also provided evidence that one specific, abundant plant miRNA, miR168, regulated the expression of low-density lipoprotein receptor-associated protein 1 (LDLRAP1) in mice. Plant miRNAs, then...
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