Induction of haem synthesis in Hep G 2 human hepatoma cells by dimethyl sulphoxide A transcriptionaily activated event Richard
نویسنده
چکیده
Exposure of cultured human hepatoma cells (Hep G2) to medium containing 2% (v/v) dimethyl sulphoxide resulted in an approximate doubling in the activity of 6-aminolaevulinate dehydratase, an increase in the haem content and a decreased growth rate; induced enzyme activity was decrease by 50% after treatment with a-amanitin. The findings are strikingly similar to those seen in murine Friend-virus-transformed erythroleukaemia cells.
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