Cross-resistance to the transplantation of syngeneic Friend, Moloney, and Rauscher virus-induced tumors.

Immimofluorescence data are presented which confirm the previously reported cytotoxic antibody studies suggesting that Friend, Moloney, and Rauscher (FMR) virus-induced lymphomas possess similar surface antigens, not shared by Gross lymphomas. It is not known, however, whether the antigenic relationship demonstrable serologically is, or should necessarily be, demonstrable by transplantation studies. To determine if tumors induced by FMR and Gross virus share transplanta tion antigens, C57BL/6 mice were pretreated with either in fectious FMR viruses, FMR lymphomas, or a Gross lymphoma and challenged with syngeneic FMR and Gross lymphomas. Mice pretreated with any one infectious FMR virus or its in duced lymphoma became resistant to the transplantation of all FMR lymphomas, but not to the Gross lymphoma. Im munization with the Gross lymphoma failed to induce re sistance to the transplantation of the FMR lymphomas, but also failed to induce resistance to itself. The results strongly suggest that FMR lymphomas possess related or identical transplantation antigens.