Ovarian Carcinoma: Recent Developments in Classification of Tumour Histological Subtype
نویسنده
چکیده
Histological types of ovarian carcinomas are distinct entities with different molecular and immunohistochemical profiles and clinical outcomes. The implementation of subtype-specific therapies for subtypes of ovarian cancer requires reproducible histological diagnoses. More than 95% of ovarian carcinomas can be reproducibly diagnosed as one of five histological types, in descending order of frequency: high-grade serous carcinoma, clear cell carcinoma, endometrioid carcinoma, mucinous carcinoma, and low-grade serous carcinoma. There are occasional cases of mixed histological type, and rare cases defy classification (adenocarcinoma not otherwise specified [NOS], or unclassifiable). Although immunohistochemical markers are a useful adjunct for the assignment of histological type, by using the modified definitions presented in this review, the majority of ovarian carcinomas can be reliably assigned to a category without recourse to immunohistochemistry.
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