Dominant and differential deposition of distinct β-amyloid peptide species, AβN3(pE), in senile plaques

Takaomi C. Saido,* Takeshi Iwatsubo,t David M. A. Mann,$ Hiroyuki Shimada,§ Yasuo Ihara,I] and Seiichi Kawashima* *Department of Molecular Biology Tokyo Metropolitan Institute of Medical Science Honkomagome, Bunkyo-ku, Tokyo Japan 1Department of Neuropathology and Neuroscience Faculty of Pharmaceutical Sciences University of Tokyo Hongo, Bunkyo-ku, Tokyo Japan tDepartment of Pathological Sciences University of Manchester Manchester England §Department of Pathology Tokyo Medical College Shinjuku-ku, Tokyo Japan IIDepartment of Neuropathology Institute for Brain Research University of Tokyo Hongo, Bunkyo-ku, Tokyo Japan