Change in body mass index among girls with precocious puberty under treatment.

INTRODUCTION Changes in body mass index (BMI) among girls with idiopathic central precocious puberty (ICPP) under treatment have been controversial in other populations. OBJECTIVE To assess changes in BMI Z score and the rate of overweight and obesity in Mexican girls with ICPP during their first year of treatment. METHODOLOGY A retrospective study was conducted among girls with ICPP under treatment with leuprolide, with a somatometry performed every six months, over a 1-year period. An analysis of variance (ANOVA) was done to establish differences in BMI Z score and a multivariate analysis was used to assess the relationship among the different factors. RESULTS Among 121 girls, BMI Z score increased from 0.87 to 1.32, and the rate of overweight and obesity increased from 40.5% to 70.3%, a statistically significant difference. CONCLUSIONS Changes in BMI Z score and the rate of overweight and obesity among Mexican girls with ICPP increased significantly.