Rapid two-step synthesis of drug-like polycyclic substances by sequential multi-catalysis cascade reactions.
نویسندگان
چکیده
An efficient amino acid-/self-/base-/ruthenium-/thermal-catalyzed two-step process for the synthesis of functionalized drug-like carbocycles was achieved through combinations of cascade TCRA/C-allylation/enyne-RCM/Diels-Alder reactions as key steps starting from simple acyclic substrates. In this communication, we report the two-step synthesis of drug-like carbocycles through a combination of organocatalysis with ruthenium-catalysis.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 8 2 شماره
صفحات -
تاریخ انتشار 2010