Albnormal Circulatory Responses to High Altitude in Subjects with a Previous History of High - Altitude Pulmonary Edema

In five men with a history of susceptibility to high-altitude pulmonary edema (HAPE), hemodynamics and pulmonary gas exchange were measured at sea level, and again 24 hours following ascent to an altitude of 3,100 m. At sea level, all findings were essentially normal including a mean pulmonary arterial pressure (Ppa) of 13.8 + 1.9 mm Hg. None of the subjects developed clinically detectable pulmonary edema at altitude. Wedge pressures and cardiac output remained normal. Ppa increased remarkably, being 38.8 + 10.3 mm Hg at rest and 53.2 11.6 mm Hg during moderate exercise. Acute relief of hypoxia only partially relieved this pulmonary hypertension. Arterial blood gases were normal at sea level. In spite of hyperventilation at altitude, arterial 02 pressure was only 50.8 + 6.1 torr at rest and fell to 41.4 3.3 torr during exercise due to a widening of the alveolar-arterial 0, pressure difference to 28.0 6.8 torr. Hence, these men susceptible to HAPE developed excessive pulmonary hypertension and impaired pulmonary O. exchange without detectable pulmonary edema following ascent to high altitude. The increase in pulmonary vascular resistance is only partially explained by hypoxic pulmonary vasoconstriction.