An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus.
نویسندگان
چکیده
In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East respiratory syndrome (MERS-CoV; previously known as human coronavirus-Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of MERS-CoV have been reported, with 54 fatalities. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. In this study, we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection.
منابع مشابه
Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus
Middle East respiratory syndrome (MERS), which is caused by a newly discovered coronavirus (CoV), has recently emerged. It causes severe viral pneumonia and is associated with a high fatality rate. However, the pathogenesis, comparative pathology and inflammatory cell response of rhesus macaques and common marmosets experimentally infected with MERS-CoV are unknown. We describe the histopatholo...
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متن کاملReply to Leow.
TO THE EDITOR—We thank Leow for his correspondence [1] in which he recognized the significance of our recent work [2]. We also welcome the constructive comments he provided concerning the limitations of our study. In our study, we focused on the in vitro cell line susceptibility of the novel coronavirus, now renamed “Middle East respiratory syndrome coronavirus” (MERS-CoV) [3]. We agree with Le...
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ورودعنوان ژورنال:
- The Journal of infectious diseases
دوره 209 2 شماره
صفحات -
تاریخ انتشار 2014