IL - 1 b is involved in temperature - associated changes in synaptic plasticity in mouse hippocampal slices
نویسنده
چکیده
The temperature at which in vitro electrophysiological experiments are performed varies widely between laboratories. Recently it was shown that the production of cytokines within brain slices is dependent upon incubation temperature (Blond et al. 2001). The pro-inflammatory cytokine interleukin-1b (IL-1b) exerts a number of neuromodulatory effects in the CNS. Therefore the aim of our study was to investigate the temperature dependency of cytokine production and synaptic plasticity in slices of hippocampus.
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