TRANSLATIONAL PHYSIOLOGY Na /Ca exchanger-1 protects against systolic failure in the Akita model of diabetic cardiomyopathy via a CXCR4/NF- B pathway
نویسندگان
چکیده
Thomas J. LaRocca, Frank Fabris, Jiqiu Chen, Daniel Benhayon, Shihong Zhang, LaTronya McCollum, Alison D. Schecter, Joseph Y. Cheung, Eric A. Sobie, Roger J. Hajjar, and Djamel Lebeche Cardiovascular Research Institute, Mount Sinai School of Medicine, New York, New York; Department of Pharmacology and System Therapeutics, Mount Sinai School of Medicine, New York, New York; and Division of Nephrology, Jefferson Medical College, Philadelphia, Pennsylvania
منابع مشابه
Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats.
The goal of the study was to determine whether defects in intracellular Ca(2+) signaling contribute to cardiomyopathy in streptozotocin (STZ)-induced diabetic rats. Depression in cardiac systolic and diastolic function was traced from live diabetic rats to isolated individual myocytes. The depression in contraction and relaxation in myocytes was found in parallel with depression in the rise and...
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متن کاملType 1 diabetic cardiomyopathy in the Akita (Ins2) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function
Basu R, Oudit GY, Wang X, Zhang L, Ussher JR, Lopaschuk GD, Kassiri Z. Type 1 diabetic cardiomyopathy in the Akita (Ins2) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function. Am J Physiol Heart Circ Physiol 297: H2096 –H2108, 2009. First published October 2, 2009; doi:10.1152/ajpheart.00452.2009.—Diabetic cardiomyopathy is an important contrib...
متن کاملType 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.
Diabetic cardiomyopathy is an important contributor to diastolic and systolic heart failure. We examined the nature and mechanism of the cardiomyopathy in Akita (Ins2(WT/C96Y)) mice, a model of genetic nonobese type 1 diabetes that recapitulates human type 1 diabetes. Cardiac function was evaluated in male Ins2WT/C96Y and their littermate control (Ins2WT/WT) mice using echocardiography and tiss...
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