Hierarchical organization of context in the hippocampal episodic code
نویسنده
چکیده
The hippocampal system appears to be critically important in establishing episodic memory of both internal and external events within contexts as well as spatial memory, which enables flexible spatial navigation. However, the neuronal substrates that function across different memories in the hippocampal system are poorly understood. I monitored large-scale activity patterns of hippocampal neuronal ensembles in rats performing a novel, continuous task that combined one visually guided and two memory-guided types of navigations in a constant environment. I found that the activity patterns of the hippocampal ensemble represent spatiotemporal contexts (journeys) constructed by temporally ordered past, present and expected future places in tandem with visually or mnemonically guided non-spatial contexts (task-demands) to form episodes. This finding therefore suggests that the hierarchical organization of contexts based on pattern separation and completion enables the hippocampus to play a dual role in spatial navigation and recall of episodic memory.DOI:http://dx.doi.org/10.7554/eLife.00321.001.
منابع مشابه
Hippocampal place cells, context, and episodic memory.
Although most observers agree that the hippocampus has a critical role in learning and memory, there remains considerable debate about the precise functional contribution of the hippocampus to these processes. Two of the most influential accounts hold that the primary function of the hippocampus is to generate cognitive maps and to mediate episodic memory processes. The well-documented spatial ...
متن کاملPhase precession: a neural code underlying episodic memory?
In the hippocampal formation, the sequential activation of place-specific cells represents a conceptual model for the spatio-temporal events that assemble episodic memories. The imprinting of behavioral sequences in hippocampal networks might be achieved via spike-timing-dependent plasticity and phase precession of the spiking activity of neurons. It is unclear, however, whether phase precessio...
متن کاملUse of Episodic Interview in Health Information Seeking Studies
Background and Aim: Due to recent attention to health promotion and self-care as one of the prerequisites of health services and intervention programs, health information seeking behavior research has gain increasing importance. Factors such as attention to user centered studies, context and self-care require using of methods and tools that help study people in their natural environment. Howeve...
متن کاملThe hippocampus, context processing and episodic memory
Contextual information plays a critical role in memory. Learned information becomes associated with the learning context and the context can cue the memories and behaviors associated with that context. An extensive literature involving experimental brain lesions has shown that the hippocampus is critically involved in processing contextual information and hippocampal output modulates processing...
متن کاملPlace field assembly distribution encodes preferred locations
The hippocampus is the main locus of episodic memory formation and the neurons there encode the spatial map of the environment. Hippocampal place cells represent location, but their role in the learning of preferential location remains unclear. The hippocampus may encode locations independently from the stimuli and events that are associated with these locations. We have discovered a unique pop...
متن کامل