Assessment of the 99th or 97.5th percentile for cardiac troponin I in a healthy pediatric cohort.
نویسندگان
چکیده
Employment or Leadership: D. Mant, Oxford University. Consultant or Advisory Role: None declared. Stock Ownership: None declared. Honoraria: None declared. Research Funding: Funding from the U.K. National Institute for Health Research Health Technology Assessment (NIHR HTA) program (project no. 99/10/99) to the Nuffield Department of Primary Care Health Sciences, University of Oxford. Expert Testimony: None declared. Patents: None declared.
منابع مشابه
Longitudinal studies of cardiac troponin I in a large cohort of healthy children.
BACKGROUND There is little information available on cardiac troponin concentrations in healthy young children. METHODS Using a precommercial high-sensitivity assay from Abbott Diagnostics, we measured cardiac troponin I (cTnI) in longitudinal blood samples collected at ages 8, 10, and 12 years from a cohort of healthy, community-dwelling children. The 99th percentile values were calculated an...
متن کاملIs it time to do away with the 99th percentile for cardiac troponin in the diagnosis of acute coronary syndrome and the assessment of cardiac risk?
The concept and use of the 99th percentile for interpretation of cardiac troponin was introduced with the redefinition of myocardial infarction in 2000, a time when few assays could detect cardiac troponin at the 99th percentile and none could meet the criteria of an assay CV of 10% at this concentration. There have been many reports of the 99th percentile providing useful information toward de...
متن کاملDetermination of 19 cardiac troponin I and T assay 99th percentile values from a common presumably healthy population.
BACKGROUND Between-assay comparability of 99th percentiles for cardiac troponin concentrations has not been assessed systematically in a single population for a large number of assays. METHODS We determined 99th percentiles for 19 cardiac troponin assays in heparin plasma samples from a population of 272 and 252 presumably healthy males and females, respectively. The assays evaluated included...
متن کاملFactors influencing the 99th percentile of cardiac troponin I evaluated in community-dwelling individuals at 70 and 75 years of age.
BACKGROUND We aimed to investigate the effects of sex, prevalent cardiovascular disease (CVD), and aging on the 99th percentile of cardiac troponin I (cTnI). METHODS cTnI was measured using a high-sensitivity assay (Abbott Diagnostics) in 814 community-dwelling individuals at both 70 and 75 years of age. We determined the cTnI 99th percentiles separately using nonparametric methods in the tot...
متن کاملPlasma 99th percentile reference limits for cardiac troponin and creatine kinase MB mass for use with European Society of Cardiology/American College of Cardiology consensus recommendations.
BACKGROUND The European Society of Cardiology/American College of Cardiology (ESC/ACC) consensus document for definition of myocardial infarction (MI) is predicated on increased cardiac troponin or creatine kinase (CK) MB mass above the 99th percentile reference limit. The purpose of this study was to determine the plasma (heparin) 99th percentile reference limits for the leading in vitro diagn...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 60 12 شماره
صفحات -
تاریخ انتشار 2014