Management of hereditary angio-oedema with low-dose danazol.
نویسندگان
چکیده
منابع مشابه
Hepatocellular carcinoma after danazol treatment for hereditary angio-oedema.
Hereditary angio-oedema is characterised by recurrent episodes of laryngeal, intra-abdominal, facial or peripheral oedema. Danazol can be used as prophylaxis for recurrent attacks. Hepatotoxicity is a recognised adverse effect of danazol. We report an exceptional case of a danazol-induced hepatocellular carcinoma in a 75-year-old patient with hereditary angio-oedema.
متن کاملSuccessful use of danazol for hereditary angio-oedema.
A 10-year-old boy with severe hereditary angio-oedema was given danazol, 200 mg each day. There was a pronounced reduction in the frequency and severity of oedema.
متن کاملHepatocellular focal nodular hyperplasia after danazol treatment for hereditary angio-oedema.
Hereditary angio-oedema (HAE) is a potentially life-threatening disease manifesting as recurrent attacks of laryngeal, intra-abdominal, facial or peripheral oedema. The disease is caused by mutations in the gene coding for C1-inhibitor, resulting in low antigenic or functional concentrations of this inhibitor of complement and kinin systems. Long-term prophylactic treatment is indicated in pati...
متن کاملHereditary angio-oedema
Hereditary angio-oedema is caused by a heterozygous deficiency of C1 inhibitor. This inhibitor regulates several inflammatory pathways, and patients with hereditary angio-oedema have intermittent cutaneous or mucosal swellings because of a failure to control local production of bradykinin. Swellings typically evolve in several hours and persist for a few days. In addition to orofacial angio-oed...
متن کاملLong-term prophylaxis in hereditary angio-oedema: a systematic review
OBJECTIVE To systematically review the evidence regarding long-term prophylaxis in the prevention or reduction of attacks in hereditary angio-oedema (HAE). DESIGN Systematic review and meta-analysis. DATA SOURCES Electronic databases were searched up to April 2011. Two reviewers selected the studies and extracted the study data, patient characteristics and outcomes of interest. ELIGIBILIT...
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ورودعنوان ژورنال:
- British medical journal
دوره 282 6272 شماره
صفحات -
تاریخ انتشار 1981